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    Lindmik Research I Jiuguang Pharmaceutical's First Transdermal Preparation Approved for the Treatment of Primary Palmar Hyperhidrosis
    Click:141  Update time:2023-04-21  【Close

    ABSTRACT

    On March 27, 2023, Japan's Jiuguang Pharmaceutical Co., Ltd. (headquartered in Bird's Nest City, Saga Prefecture, Japan; President and CEO: Kazuhide Nakatomi) announced that it had obtained APOHIDE ? Lotion, with 20% production and sales approval, is the first drug in Japan to treat hand sweating (R&D code: HP-5070, generic name: Oxibunin Hydrochloride, hereinafter referred to as "this product").


    Primary palmar hyperhidrosis is a disease characterized by excessive palmar sweating and is known to be a major factor in reducing the quality of life and labor efficiency in various aspects of school and social life, as it can seriously interfere with social activities (such as shaking hands, clerical work, and electronic device operation)。


    This product is an topical topical formulation developed using Jiuguang's TDDS (transdermal delivery system) technology, and is the first drug in Japan to demonstrate efficacy and safety in phase III clinical studies targeting patients with primary palmar hyperhidrosis.


    With this approval, Jiuguang Pharmaceutical expects the product to be applied to the palm of the hand once a day before bedtime, which will become a new choice for treating primary palmar hyperhidrosis.


    Attached product production and marketing license notice:

    Source (Network)


    Basic Product Information

    Product:APOHIDE ? Lotion 20%

    Main ingredient: Oxybutin hydrochloride
    Indications: Primary palmar hyperhidrosis
    Usage and dosage: Once a day before bedtime, take an appropriate amount onto both palms.
    Attention: One application should be equivalent to five pump strokes per palm of both hands.
    Packaging specification: 4.5mL (plastic container) x 20 bottles


    來源(網絡)


    Three topical anticholinergic drugs for primary hyperhidrosis as of March 2023

    Product name Sofelonium bromide gel 5% Gelong ammonium bromide napkin 2.5% Oxibunin lotion 20%
    Common name Sofirolomide bromide GLYCOPYRROLATE Oxybutynin
    Effectiveness Primary axillary hyperhidrosis Primary palmar hyperhidrosis
    Usage and dosage Once a day, apply an appropriate amount to the armpit. Once a day, one package contains a piece of non-woven fabric, and the solution is applied to both armpits. Once a day, apply an appropriate amount to the palms of both hands before going to bed (with the target of pressing the pump head 5 times on both palms).
    Taboo

    ·Angle closure glaucoma;

    ·Urinary disorders caused by prostate enlargement;

    ·Previous history of allergies to the ingredients of this preparation.

    ·Angle closure glaucoma;

    ·Urinary dysfunction caused by lower urinary tract occlusion disease (prostate enlargement, etc.);

    ·Severe heart disease;

    ·Intestinal obstruction or paralytic intestinal obstruction;

    ·Myasthenia gravis;

    ·Previous history of allergies to the ingredients of this preparation.

    Specific background patient precautions ·Specific background patient precautions: Prostate hypertrophy (excluding urinary disorders), trauma, eczema, dermatitis, etc. can be seen at the application site.

    ·Specific background patient precautions: Prostate hypertrophy (excluding urinary disorders), hyperthyroidism, congestive heart failure, arrhythmia, ulcerative colitis, Parkinson's symptoms or cerebrovascular disorders, dementia or cognitive impairment, trauma, eczema, dermatitis, etc. can be seen at the application site;

    ·Severe renal dysfunction;

    ·Severe liver dysfunction.

    Mother-to-be ·Administer only when it is judged that the therapeutic benefits outweigh the risks ·Suggest not to use
    Children ·Not allowed to use under the age of 12 ·Not allowed to use under the age of 9 ·Not allowed to use under the age of 12
    Last:Lindmik Research I FDA Update General Transdermal and Local Drug Delivery System Guidelines
    Next:Sinopharm Holdings and Leming Pharmaceutical jointly sign a strategic cooperation agreement

    LINDMIK PHARMA

    Lindmik Pharmaceutical(Suzhou)Co.,Ltd is a high-tech pharmaceutical enterprise focusing on the research and development, production and sales of innovative pharmaceutical preparations.Equipped with a number of its own innovative R&D platform of dosage forms, including the transdermal drug delivery system, and at the same time, actively introducing the world’s leading nano-based drug delivery, microspheres drug delivery and other cutting-edge pharmaceutical technologies by means of “license in”, the company is a new rapidly developing company pharmaceutical companies that catches people’s eyes.

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